Sparking Gut Bacteria Production of Bioactive Xenolipids in Situ

Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Long-chain cyclopropane fatty acids (CpFAs) are microbially-derived lipids (fats), some of which can be found in select foods and appear to be produced naturally in the gut from dietary fatty acid precursors. Some of these lipids appear to have signaling properties in the body's tissues, i.e., to help regulate cardiometabolic health. Thus, increasing the bioavailability of CpFAs in humans may have utility to improve management of blood sugar and blood lipids, or to mitigate or prevent non-alcoholic fatty liver disease (NAFLD). This study is a proof-of-principle experiment in 10 subjects, to feed dietary fats thought to enhance upper gut CpFA production. The latter will be monitored through post-meal blood and urine CpFA concentration measurements, as well as concentration in the stool.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: t
View:

• Men and women aged 18 to 50, with a Body Mass Index (BMI) categorized normal through overweight (18.5-29.9 kg/m2) and able to provide informed consent in English will be recruited to the study.

Locations
United States
California
University of California, Davis School of Medicine
RECRUITING
Sacramento
Contact Information
Primary
Sean H. Adams, PhD
shadams@ucdavis.edu
916-734-4868
Time Frame
Start Date: 2024-04-01
Estimated Completion Date: 2025-05-31
Participants
Target number of participants: 10
Treatments
Experimental: Dietary fat with negative control supplement
Dietary fat-containing meal plan with a specific supplement that should not modify fat metabolism
Experimental: Dietary fat with positive control supplement
Dietary fat-containing meal plan with a specific supplement that may modify fat metabolism
Related Therapeutic Areas
Sponsors
Leads: University of California, Davis

This content was sourced from clinicaltrials.gov